Tuesday, April 2, 2013

Buscemi to direct Vampire Weekend live stream

(AP) ? Steve Buscemi (boo-SHEM'-ee) will direct a live stream of a Vampire Weekend concert to debut a new season of "Unstaged."

The stream will launch the fourth season of "American Express Unstaged," an online series that pairs notable directors with popular music acts. Vampire Weekend's concert at the Roseland Ballroom on April 28 will stream live on VEVO and YouTube.

American Express was to officially announce the live stream Tuesday.

Vampire Weekend lead singer Ezra Koenig in a statement called Buscemi "a wonderful actor, a NYC legend and a great director." Buscemi has directed four feature films, including 1996's "Trees Lounge," as well as several "Sopranos" episodes.

Vampire Weekend will release their third album, "Modern Vampires of the City," on May 14.

___

Online:

http://www. amexunstaged.com

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-04-02-Live%20Stream-Vampire%20Weekend/id-52da32566e6c42e5b0d2f9fd50072c50

kowloon walled city ronda rousey vs miesha tate lindsay lohan snl lindsay lohan on snl real housewives of disney awakenings phantom of the opera

'RNA sponge' mechanism may cause ALS/FTD neurodegeneration

Tuesday, April 2, 2013

The most common genetic cause of both ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) was recently identified as an alteration in the gene C9orf72. But how the mutation causes neurodegenerative disease appeared mysterious.

Researchers at Emory University School of Medicine have demonstrated that this ALS/FTD mutation may be harmful because it creates an "RNA sponge," soaking up an important regulatory protein that binds RNA.

The results were published online Monday in the Proceedings of the National Academy of Sciences, Early Edition.

"We think that the RNA itself is part of the disease mechanism," says co-author Thomas Wingo, MD, assistant professor of neurology at Emory University School of Medicine. "In both cell culture and fruit flies, we've been able to show that we can add back the protein depleted by the RNA and ameliorate the problem."

The finding provides insight into the mechanism of disease in ALS and FTD, both in cases where C9orf72 is altered and in other cases. It suggests some forms of ALS/FTD may have common elements with other neurodegenerative disorders caused by noncoding repeats, such as myotonic dystrophy, spinocerebellar ataxia and fragile X-associated tremor/ataxia syndrome.

The senior author is Peng Jin, PhD, professor of human genetics at Emory University School of Medicine. The first authors are a former graduate student, Zihui Xu, PhD, now at Huazhong University of Science and Technology in China, and research specialist Mickael Poidevin.

ALS is a fatal disease in which motor neurons in the brain and spinal cord degenerate. As the illness progresses, patients lose the ability to walk, talk and breathe. FTD is a form of dementia in which the patients primarily experience deterioration in behavior, personality or language.

Many neurologists and researchers consider these conditions as sharing clinical and pathological features. Mutations in several genes have been linked to both ALS and FTD, which suggests that they have a common mechanism. However, most cases are considered sporadic, meaning that they don't have a clear family history.

In 2011, a mutation was identified within C9orf72 as the most common genetic cause of ALS and FTD, accounting for 5 to 7 percent of cases of each disease. The mutation doesn't seem to affect the protein encoded by C9orf72. Instead, it expands a block of repetitive DNA, so that the sequence "GGGGCC" is repeated hundreds of times outside the parts of the gene that encode protein.

This looks similar to "noncoding repeat" expansions responsible for other neurodegenerative disorders such as myotonic dystrophy, spinocerebellar ataxia and fragile X-associated tremor/ataxia syndrome.

Some researchers have reported that the GGGGCC repeat produces RNA that is translated into an unusual protein that aggregates in cells. These protein aggregates are thought to be toxic to neurons. Emory researchers have an alternative explanation: the GGGGCC repeat RNA itself is toxic.

The Emory team tested the effects of producing the GGGGCC repeat RNA, which proved toxic to cultured mammalian neuronal cells and caused neurodegeneration in fruit flies. When the repeat RNA was produced in flies' motor neurons, the flies had reduced motor activity.

The repeat RNA appears to be harmful because, when overproduced, it sequesters a protein called Pur alpha, which sticks to the GGGGCC repeats. Scientists had previously found that Pur alpha is necessary for neuronal development and is involved in the transport of RNA within neurons. Making neuronal cells or flies produce more Pur alpha to compensate reverses the toxicity caused by the RNA, the Emory scientists found.

"For ALS and FTD, this suggests a disease-fighting strategy of targeting either the toxic RNA itself or its interaction with Pur alpha," Jin says. "It also hints that there is a common RNA-based mechanism contributing to several neurodegenerative diseases."

Sequestering Pur alpha appears to cause its redistribution within the neurons of patients affected by ALS/FTD. The Emory team was able to detect clumpy "inclusions" containing Pur alpha in samples of brain tissue from individuals with C9orf72 mutations ? and also in other individuals with FTD but without C9orf72 mutations.

###

Emory Health Sciences: http://whsc.emory.edu/home/news/index.html

Thanks to Emory Health Sciences for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 31 time(s).

Source: http://www.labspaces.net/127545/_RNA_sponge__mechanism_may_cause_ALS_FTD_neurodegeneration

Usain Bolt 2012 Olympics Katie Ledecky Aaron Ross Sikh temple Nastia Liukin Gabby Douglas hair Kayla Harrison

Zinio Guest Post: What's your favorite digital magazine?

Can the iconic magazine maintain the people?s choice status? Cast your vote.

At Zinio we?re always adding new high quality magazines from around the world. We strive to add a unique mix of magazines. From long time favorites, to iconic titles, niche newcomers and even innovative international titles, we want our readers to always find something that matches their passions.

The Zinio catalog is currently filled with over 5,500 of the world?s best digital magazines. But, you?d be surprised to see which titles are actually voted by our readers as the favorites. We decided to open up the voting to the Android Apps community. Scroll through some of the newest additions to Zinio, browse our store and then cast your vote in the comments. We also invite you to share your favorites with the Android Apps?Facebook and Twitter communities.

The winner of the Appolicious reader?s choice for ?favorite? magazine to read digitally on Zinio will be shared in a few weeks. Until then, check out some of our new additions:


Vanity Fair

I doubt there are many strangers to Vanity Fair. It is, however, fairly new to the Zinio newsstand in the US. The magazine has always done a great job walking the line between legit celebrity fascination and tabloid voyeurism. Throw in some award winning investigative journalism and you have Vanity Fair. But the underrated part of the magazine that shines in its digital iteration is the photography. It arguably employs the best photographers in the business and you will be surprised how sharp and illuminating it looks on a tablet. It?s a complex layout that translates surprisingly well to digital formats of all types.


Fast Company

It?s a business magazine that covers lifestyles. And a lifestyle magazine that covers business. Check the newest issue of Fast Company and get the scoop on trends in Hollywood and you?ll see what I mean. For me, the best judgment of any business magazine is in the archives. Were they right in their predictions? Did they pick the winning companies. Fast Company?s digital publishing archive pulls no punches. And by the way, their Fast 50 has been pretty spot on over the years.


The Atlantic

The oldest magazine. Period. New to Zinio within the past year, I have written previously about the innovations The Atlantic has engineered in terms of mobile and PC-based design, which are both outstanding. For me, The Atlantic is all about discovery. I can read about toddler behavior in the tech era, robots, foreign policy or the gun control debate? I?m always surprised. Like Fast Company, the archives are incredibly valuable. It?s just that at The Atlantic, the archives go back 125 years. It is American history gone digital.


Geek

Great new magazine, and it is what it says it is: If you?re a Star Trek, anime aficionado, gamer, gadgethead or know someone who is, Geek is the geekiest. It is built for digital publishing because of the subject matter. It is also a great addition to Zinio because it captures so many subject areas (film, music, games, TV, other magazines) and because it reaches a great niche.


Howler

Soccer with attitude. Howler is a new magazine about soccer covering the global game from the perspective of North American fans. It?s a big, glossy publication that will come out four times a year with distinctive, original writing, as well as some of the most striking art and design you?ll find anywhere.

And those are just a few of the over 5,500 titles we carry. My favorite magazine to read on Zinio used to be US Weekly, then it switched to Star Trek Magazine (I know!), then New Scientist, but these days I find myself obsessed with Harvard Business Review. How about you?

Like me, I am sure your favorite will change frequently, but add a comment and let us know: What is the best magazine you?ve added to your digital magazine experience so far this year? As we?ve done, give us the old ones that have found new life. Or better yet, give us the ones that you have discovered and added as a brand new title.

To participate, share your comments in this article. We also invite you to share your favorites with the Android Apps Facebook and Twitter communities.

Source: http://www.androidapps.com/tech/articles/13353-zinio-guest-post-what-s-your-favorite-digital-magazine

joe biden michelle obama lupe fiasco jason wu jason wu Mavericks Surf Stonewall

Contain this (Powerlineblog)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/295815094?client_source=feed&format=rss

ipad mini Kevin Krim Autumn Pasquale ann coulter minecraft Ben Wilson Latest Presidential Polls

Monday, April 1, 2013

Astros strong in AL debut, top Texas in MLB opener

HOUSTON (AP) ? Rick Ankiel and the Houston Astros made an impressive debut in the American League, trouncing the Texas Rangers 8-2 Sunday night in the major league opener and giving Bo Porter a win in his first game as manager.

Ankiel launched a pinch-hit three-run shot for the first homer this season, Bud Norris pitched well for the win and Erik Bedard threw 3 1-3 scoreless innings for his first career save.

Having switched from the National League to the AL in the offseason, the Astros earned their first opening day victory since 2006 and the 4,000th regular-season win in franchise history.

The Astros are coming off consecutive 100-loss seasons and has the lowest payroll in the majors, prompting many to predict they will be the worst team in the majors. But Houston opened in style wearing spiffy new uniforms that brought back the orange and blue of old-school Astros teams.

Justin Maxwell added a pair of triples and made a nifty catch in center field.

Norris (1-0) allowed five hits and two runs with five strikeouts in 5 2-3 innings. He was one of five Astros making their first opening day start on baseball's second-youngest team.

Bedard shut down the Rangers on one hit the rest of the way for his first save in a 10-season career.

As Houston began a new era with the move to the AL, the Rangers were embarking on a new chapter without 2010 AL MVP Josh Hamilton. Along with Hamilton's departure to the Angels, Texas also lost catcher Mike Napoli and infielder Michael Young.

The loss snapped a streak of four straight opening day victories by the Rangers. Former Astros star Lance Berkman had two hits in his first game as Texas' designated hitter.

Matt Harrison (0-1), who signed a $55 million contract this offseason, yielded six hits and five runs and tied a career high with nine strikeouts in 5 2-3 innings.

Maxwell's two-out triple in the fourth inning broke a scoreless tie and gave Houston a 2-0 lead. The ball bounced off the wall in left field and scored Brett Wallace and Carlos Pena, who both got on with singles. Umpires reviewed the play to make sure it wasn't a home run, and upheld the call.

An error by right fielder Nelson Cruz let Houston score a run in the fifth, and Jose Altuve singled home another.

Harrison put runners at first and second with walks in the sixth and was replaced by Derek Lowe with two outs. Ankiel, the one-time pitcher with St. Louis, connected on his fifth career pinch-hit homer, a full-count shot to right field that made it 7-2.

Norris had a tough second inning and had to use 26 pitches to escape, striking out Mitch Moreland. Norris got on a roll from there, retiring nine of the next 10 batters.

Norris ran into trouble in the sixth when Ian Kinsler drew a walk and Berkman hit a one-out single. Murphy's two-out single sent Kinsler home to make it 4-1. Cruz followed with a groundball single that rolled just out of reach of diving shortstop Ronny Cedeno to score Berkman and chase Norris.

Chants of "Cruuuuuuuz" filled the stadium, indicating the large number of Rangers fans who made the 250-mile trip from Dallas. Norris was replaced by Erik Bedard, who is Houston's fifth starter, but won't be needed for a while in the rotation because of off-days.

NOTES: Altuve got the first hit of the 2013 season. ... These teams have a day off Monday before resuming the series on Tuesday when the Rangers' Yu Darvish opposes Lucas Harrell. ... Houston Texans defensive end J.J. Watt, the NFL's defensive player of the year, threw out the ceremonial first pitch. Watt, who said he threw a bullpen session to prepare for the task, threw a strike. ... Texans star receiver Andre Johnson was also in the sold-out crowd of 41,307. ... Lyle Lovett performed the national anthem.

Source: http://news.yahoo.com/astros-strong-al-debut-top-texas-mlb-opener-031532990--mlb.html

jersey shore Pasquale Rotella Michael Clark Duncan michael jackson courtney stodden Ncaa Football Scores Plaquemines Parish

Pats 'don't need Ed Reed' with Wilson

dt.common.streams.StreamServerAP

From time to time over the past few years, former Patriots safety Rodney Harrison has explained that his former teams needs to add a player like, well, him.

Finally, he thinks they have in Adrian Wilson, who was signed by New England after being cut by the Cardinals.

?Adding him, the veteran leadership, the presence, the respect factor, he?s a guy that?s a terrific blitzer, and a physical presence,? Harrison told Karen Guregian of the Boston Herald.? ?I think he can come in especially during nickel and dime situations, and come down [close to the line] and play that second linebacker position like I did.? He?s physical enough to help out in the run game, but he can also cover tight ends. So he can be that guy next to [Jerod] Mayo who can come in and really make a difference in that nickel and dime package. .?.?. It?s a fantastic move.? I think he?ll help the Patriots immediately.? I think he?ll hold people accountable.?

But what about Ed Reed?? Many believed that Pats coach Bill Belichick would make a beeline for the now-former Raven, who signed with the Texans.?For what the Patriots need, they don?t need Ed Reed.? They need an Adrian Wilson,? Harrison said.? ?They don?t need a free safety that can intercept balls.? They have that.? Devin McCourty is that Ed Reed [role].? He doesn?t have that name behind him.? But he is developing into a young safety.? They need a guy like Adrian Wilson who can really give them versatility in those nickel and dime packages.? He?ll help that secondary right away.?

Harrison recognizes that Wilson has lost a step, but he?s at a point in his career where every player loses a step.

?The one question he?ll have to answer, will he be a full-time, every down safety?? Harrison said.? ?Can he cover in open space?? Will he be able to cover the deep half of the field?? That?s a lot of questions.? But I?ll say it again, I think this is a good move for the Patriots.?

For a team with an offense that has been good enough in recent years to win another Super Bowl, Wilson could be the guy who helps make the difference on the defensive side of the ball.

Source: http://profootballtalk.nbcsports.com/2013/03/31/rodney-harrison-thinks-pats-got-it-right-with-adrian-wilson/related

nfl draft d rose iman shumpert mayweather vs cotto shumpert hopkins hopkins

Texas DA slain in his home; had armed himself

KAUFMAN, Texas (AP) ? Kaufman County District Attorney Mike McLelland took no chances after one of his assistant prosecutors was gunned down two months ago. McLelland said he carried a gun everywhere he went and took extra care when answering the door at his home.

"I'm ahead of everybody else because, basically, I'm a soldier," the 23-year Army veteran said in an interview less than two weeks ago.

On Saturday, he and his wife were found shot to death in their rural home just outside the town of Forney, about 20 miles from Dallas.

While investigators gave no motive for the killings, Forney Mayor Darren Rozell said: "It appears this was not a random act."

"Everybody's a little on edge and a little shocked," he said.

The slayings came less than two weeks after Colorado's prison chief was shot to death at his front door, apparently by a white supremacist ex-convict, and two months after Kaufman County Assistant District Attorney Mark Hasse was killed in a parking lot a block from his office. No arrests have been made in Hasse's slaying Jan. 31.

McLelland, 63, is the 13th prosecutor killed in the U.S. since the National Association of District Attorneys began keeping count in the 1960s.

Sheriff David Byrnes said Sunday that there was nothing to indicate for sure whether McLelland's slaying was connected to Hasse's. He declined to discuss it further. The sheriff also said he had no indication that white supremacist groups were involved in the killing of the DA.

Colorado's corrections director, Tom Clements, was killed March 19 when he answered the doorbell at his home outside Colorado Springs, Colo. Evan Spencer Ebel, a former Colorado inmate and white supremacist who authorities suspect shot Clements, died in shootout with Texas deputies two days later about 100 miles from Kaufman.

El Paso County, Colo., sheriff's spokesman Sgt. Joe Roybal said Sunday that investigators had found no evidence so far connecting the Texas killings to the Colorado case, but added: "We're examining all possibilities."

McLelland, in an Associated Press interview shortly after the Colorado slaying, raised the possibility that Hasse was gunned down by a white supremacist gang. McLelland, elected DA in 2010, said that Hasse hadn't prosecuted any cases against white supremacists but that his office had handled several, and those gangs had a strong presence in and around Kaufman County, a mostly rural area dotted with subdivisions, with a population of about 104,000.

"We put some real dents in the Aryan Brotherhood around here in the past year," McLelland said.

McLelland said he carried a gun everywhere he went, even to walk his dog around town, a bedroom community for the Dallas area. He figured assassins were more likely to try to attack him outside. He said he had warned all his employees to be constantly on the alert.

"The people in my line of work are going to have to get better at it," he said of dealing with the danger, "because they're going to need it more in the future."

The number of attacks on prosecutors, judges and senior law enforcement officers in the U.S. has spiked in the past three years, according to Glenn McGovern, an investigator with the Santa Clara County, Calif., District Attorney's Office who tracks such cases.

For about a month after Hasse's slaying, sheriff's deputies were parked in the district attorney's driveway, said Sam Rosander, a McLelland neighbor.

The FBI and the Texas Rangers joined the investigation into the McLellands' deaths.

McLelland and his wife, Cynthia, 65, were the parents of two daughters and three sons. One son is a police officer in Dallas. The couple had moved into the home a few years ago, Rozell said.

"Real friendly, became part of our community quickly," Rozell said. "They were a really pleasant happy couple."

___

Riccardi reported from Denver. Associated Press writers Michael Graczyk in Houston, Angela K. Brown in Fort Worth and P. Solomon Banda in Denver contributed to this report.

Source: http://news.yahoo.com/texas-da-slain-home-had-armed-himself-175942683.html

nascar bristol narwhal st louis university mario manningham mario manningham williams syndrome hoya